The Foundation for the National Institutes of Health is announcing a new Request for Proposals (RFP) to augment and expand the Type 2 Diabetes Knowledge Portal.
RFP16, due April 15, aims to facilitate prioritization of potential causal variants or genes in risk loci or
credible sets by:
a. Developing preliminary functional annotation data to support strength of evidence for
candidate genes for diabetes and complications (cardiovascular, obesity, diabetic and
chronic kidney disease, NASH and liver function, diabetic retinopathy, glycemic traits);
and/or
b. Generating mechanistic hypothesis for causal genes from cell-based genome-wide
functional or perturbation studies (e.g. RNA-Seq, ATAC-Seq, CHIP-Seq, others);
and/or
c. Developing and employing novel tools such as CRISPR tiling to combine with readout
such as RNA-Seq to enable prioritizing potential causal variants or genes.
Find full details and contact information here.
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